In 1993, Sarah McLachlan was likely best known for "Possession," a haunting song from her third album with lyrics from the point of view of a stalker. By the turn of the century, McLachlan may have been most famous for establishing Lilith Fair, the all-female music tour.

In 2014, though, McLachlan's most famous contribution to pop culture may just be "Angel," the song backing ASPCA commercials that air in PSA spots on late-night television. Brutally effective when paired with photos and video of dogs and cats in cages, could "Angel" be used to promote other causes or even brands? Let's pair ?