Spring break is synonymous with partying co-eds. But if you're looking for a vacation with some peace and quiet, here are four destinations where you are likely to avoid the college crowds.

Paso Robles, California

For those looking to combine luxury, comfort and winetasting, head to this community located midway between San Francisco and Los Angeles. Enjoy the comfortable 80-degree temperatures while wining and dining at wineries like JUSTIN Vineyards, where guests can explore wine caves 120 feet underground and stay on the premises at its lavish hilltop manor.

Sanibel Island, Florida

Quiet white sand beaches, isolated spots and wildlife can all be found on the west side of South Florida. Watch more than 250 species of birds at the J.N "Ding" Darling National Wildlife Refuge, go shelling, take a nature cruise, paddle the Great Calusa Blueway or windsurf the Sanibel Causeway.

Vieques Island, Puerto Rico

This Puerto Rican paradise is accessible by ferry -- enough of a journey to discourage spring breakers. Once you get there, scuba-driving, snorkeling, mountain biking and horseback riding await. When you're ready to relax, choose from more than 30 custom spa treatments at a resort like W Retreat & Spa.

Punta Cana, Dominican Republic

On the easternmost edge of the Dominican Republic, you can find a little something for everyone. Beach bums can relax on five miles of white sand, golfers can play two award-winning courses, kids can visit a petting zoo, adventure seekers can swim in lagoons or take kite-boarding lessons, spa lovers can relax at resorts like the Puntacana and those looking for some festive fun can take part in the annual Carnaval celebration, from March 7-10.