Injuries have run rampant early in the 2014 season. While no one ever likes to see players get hurt, we can’t afford to ignore the fantasy football impact. To help you adjust to the new landscape, here is the latest on some of the recently injured players.

Jamaal Charles (RB, Chiefs)

Charles suffered a dreaded high ankle sprain last Sunday, and his timetable to return is uncertain. Even worse, it is unclear how effective he will be playing on a bum ankle, as a similar injury derailed the season of C.J. Spiller (RB, Bills) just last year. While Charles is out of the lineup, Knile Davis becomes an RB1 and easy weekly start.

Ryan Mathews (RB, Chargers)

The injury-prone Mathews suffered a knee injury that is likely to keep him sidelined for four to five weeks. Expect Donald Brown to pick up his role in the offense and become a viable flex starter. Don't be afraid to target him aggressively if he is still a free agent in your league.

Knowshon Moreno (RB, Dolphins)

Moreno seemed primed to prove doubters wrong with another great year in the new up-tempo Dolphins offense. Unfortunately, a dislocated elbow will sideline him for four to eight weeks, opening the door for Lamar Miller to become an RB2 in his absence.

A.J. Green (WR, Bengals)

The Bengals have not been transparent about the severity of Green's toe injury, which could hold him out anywhere from one to four weeks. In the meantime, expect the Bengals to lean on RBs Gio Bernard and Jeremy Hill.

Washington Redskins

It seems like half of the Redskins' offense, including centerpiece Robert Griffin III (QB), is now injured. While DeSean Jackson and Jordan Reed could be ready as soon as next week, Griffin may miss half of the season. Do not be surprised if Kirk Cousins leads a more conservative offense in his absence, decreasing the fantasy value of everyone except, perhaps, Alfred Morris (RB).

Alex Case is amNY's fantasy football columnist.