PORT ST. LUCIE, Fla. — Jenrry Mejia was called for his third strike. And now, the Mets reliever is out of baseball.

Major League Baseball slapped Mejia with a lifetime suspension after he tested positive for Boldenone, his third violation of the league’s performance-enhancing drug policy.

Mejia, 26, is the first player to receive a lifetime ban under baseball’s steroid policy. He had already been serving a 162-game suspension for his last violation.

“We were deeply disappointed to hear that Jenrry has again violated Major League Baseball’s Joint Drug Prevention and Treatment Program,” the Mets said in a statement. “We fully support MLB’s policy toward eliminating performance enhancing substances from the sport. As per the Joint Drug Program, we will have no further comment on this suspension.”

Last July, Mejia was suspended for 162 games for a second PED offense, which came just three weeks after returning from the 80-game sanction he earned in April. Mejia tested positive for Stanozolol and Boldenone last July.

Other baseball players banned for life

Chicago White Sox pitchers Eddie Cicotte and Lefty Williams, first baseman Chick Gandil, shortstop Swede Risberg, third baseman Buck Weaver, outfielders Joe Jackson and Happy Felsch and infielder Fred McMullin. Banned March 12, 1921, by commissioner Kenesaw Mountain Landis, for their involvement in throwing the 1919 World Series.

Philadelphia Phillies infielder Gene Paulette. Banned March 21, 1921, by Landis, for accepting a loan from Elmer Farrar that was tied to a gambling scheme.

New York Giants outfielder Benny Kauff. Banned April 7, 1921, by Landis, for indictment on charges of auto theft and possession of a stolen car. Kauff was acquitted but never reinstated.

New York Giants pitcher Phil Douglas. Banned Aug. 18, 1922, by Landis, for writing a letter to St. Louis Cardinals outfielder Leslie Mann in which Douglas asked Mann to throw a game.

New York Giants outfielder Jimmy O’Connell and coach Cozy Dolan. Banned Oct. 1, 1924, by Landis, for offering a $500 bribe to Philadelphia Phillies shortstop Heinie Sand to throw a game.

Philadelphia Phillies president William D. Cox. Banned Nov. 23, 1943, by Landis, for “approximately 15 or 25 bets” of “from $25 to $100 per game on Philadelphia to win.”

Cincinnati Reds manager Pete Rose. Banned Aug. 23, 1989, by commissioner A. Bartlett Giamatti, for gambling on Reds games.