Construction work will affect subway riders on 12 lines this weekend, as well as the Times Square shuttle, according to the MTA.

The changes include the suspension of the No. 1 train between 14th Street and South Ferry and the No. 2 and No. 3 trains running local between 34th Street-Penn Station and Chambers Street.

On the Lexington Avenue line, the uptown No. 4 and No. 5 will run local between Grand Central-42nd Street and the 125th Street stations. The No. 5 train will run only every 20 minutes.

Brooklyn riders on the No. 4 will have to take shuttle buses between the Crown Hts-Utica Avenue station and New Lots Avenue.

The No. 7 train will run express on Saturday and Sunday from the morning to the evening from Mets-Willets Point to 74th Street-Broadway in Queens.

The Times Square Shuttle will be suspended from 6:30 a.m. to midnight on Saturday and Sundays. Riders should take the No. 7 train instead.