Road closures in the Hofstra University campus area have begun ahead of the debate.
Until midnight, Charles Lindbergh Boulevard and Earle Ovington Boulevard will be closed, as will Hempstead Turnpike from Oak Street to Merrick Avenue near Eisenhower Park. Oak Street will also be closed from Hempstead Turnpike, northbound, to Westbury Boulevard.
California Avenue and Meadowbrook Place will be closed, northbound, at Belmont Place. Uniondale Avenue and Manor Parkway will be closed, headed north, at McKenna Place.
Nassau County officials are urging drivers to use other eastbound or westbound routes: Front Street, Old Country Road, or Stewart Avenue.
Lawrence Street in Uniondale will become a one-way street, heading north from Hempstead Turnpike to Westbury Boulevard; Courtenay Road in Hempstead can be accessed one-way, headed south from Hempstead Turnpike to Front Street.
Manor Parkway, Marvin Avenue, Walton Avenue, Gilroy Avenue and Cunningham Avenue will become one-way streets, for one block south of Hempstead Turnpike.
There will be no parking on Oak and Lawrence streets, Courtenay Road and McKenna Place.
Traffic delays and updates will be projected on six electronic portable message signs.