The cold weather is getting the best of many of us.

With record-low temperatures in New York City, residents are feeling the effects in different ways.

According to psychologist John Grohol, research has shown moods and thought processes can be directly affected by cold weather, with an increase in tension, depression, anger and fatigue.

"If you're used to a certain climate and suddenly you're going through extreme temperatures, that's something that will take some getting used to," said Grohol, who is also the founder of PsychCentral, an online mental health forum. "There could definitely be a negative impact on people's health."

The temperature isn't the only change in people's routines, experts said.

"Parents are coping with their children's school closures, people are missing work, and many of their social patterns have been disrupted," said Kathryn Salisbury, a spokeswoman for Mental Health Alliance of New York City. "All these things really contribute to stress."

Salisbury said the cold weather impacts those suffering from chronic aches and pains, adding that frigid temperatures tend to aggravate respiratory conditions like Asthma.

In addition to daily exercise, Salisbury advises New Yorkers to maintain contact with family and friends, whether it's staying in touch by phone or braving the cold to see them.

"We have to be creative about how to keep ourselves active at this time of year," Salisbury said. "You may have to change your activities, but the key is to stay active and engaged with those around you."

For New Yorkers like Hassan Metwally, there's no choice but to adapt to the bone-chilling temperatures. Manning the food cart at 35th Street and Seventh Avenue for 10 hours a day, he experiences the physical and financial challenges of a New York winter.

"The money has been really slow since October," said Metwally, 35, who is originally from Egypt. "It's been too cold, so not a lot of people stop here now. Hopefully March brings the spring."

Until the spring, New Yorkers who can no longer bare the cold flee to more tropical climates. Glenda Abreu, 36, kept warm in Manhattan Mall while picking up some last-minute items for her trip to Panama.

"I am in no way getting used to how cold it has been," Abreu said. "I was born and raised in New York City, but I can't wait to get out of here."