It was a forgettable Week 5 of the NFL season with losses from the New York Giants, New York Jets, and the Los Angeles Chargers dropping the running record to 10-5 in 2025. It was a solid run to open the season, but the NFL will bite you every now and then. Sorry about that! We still have high hopes for Week 6!
There are some intriguing matchups entering Week 6 that will allow you to advance into Week 7 of your elimination challenge or survivor pool. We take a risk this weekend by picking a toss-up contest that even that even the AI-algorithm didn’t want to choose between. So, strap in and get ready for another glorious week of NFL football in Week 6.
New England Patriots (at New Orleans Saints)
New England rolls into Louisiana on a two-game winning streak, including a stunning takedown of the Buffalo Bills in a divisional contest in Week 5. New Orleans secured their first victory of the 2025 campaign by scoring 26 points against the New York Giants last weekend. There is a major difference between the quality of opponents last week, so except the Patriots roll to a win on Sunday afternoon.
QB Drake Maye has completed 74% of his passes (113-of-153) for 1,261 yards, seven touchdown passes, and two interceptions through the early part of the season. The second-year QB could use some more help from the ground game this season with no Patriots running back averaging more than 30 yards per game (Y/PG) in 2025. Rhamondre Stevenson leads the way with 139 yards on 38 carries through five contests (an average of 27.8 Y/PG) .
New England enters the road contests with a 59.7% to win in Week 6, according to ESPN Analytics.
Seattle Seahawks (at Jacksonville Jaguars)
The Jacksonville Jaguars are looking for a 5-1 start for the first time since 1999, but they will be denied by a Seattle Seahawks squad that has been flying high all season. Jacksonville enters with a better record at 4-1, including a one-score victory over the Kansas City Chiefs in Week 5. Still, the Seahawks two losses (Tampa Bay and San Francisco) are to some of the best competition the NFC has to offer.
QB Sam Darnold has the Seahawks soaring with a 73% completion rate (98-of-134 passes) for 1,246 yards, nine touchdown passes and three interceptions in 2025. RB Kenneth Walker III has recorded 330 yards on 68 carries with three touchdown runs as he paces the Seattle ground game. RB Zach Charbonnet has recorded 132 yards on 48 carries, but he also has three touchdowns this season, so he will be a name to watch in that Seahawks backfield on Sunday.
The ESPN Analytics model doesn’t have a clear victor provided in its matchup predictor in this game. Both squads are listed at a 49.8% chance of victory. So, naturally, let’s be bold and pick Seattle here.
Green Bay Packers (vs. Cincinnati Bengals)
New Bengals QB Joe Flacco took down the Green Bay Packers in Week 3 as a member of the Cleveland Browns. Now, he will get the opportunity to win a game against Green Bay for the other Ohio-based football squad. Despite his veteran NFL status, that is a tall task for Flacco to step into a new environment and take down a team with Super Bowl aspirations in Green Bay.
As for the Packers, they enter Week 6 after a tie against the Dallas Cowboys last weekend on Sunday Night Football. Green Bay’s offense is led by QB Julian Love, who enters Week 6 with a perfect 1,000 passing yards on 84-of-121 throws, with eight touchdowns and one interception this season. The Packers have gotten little help from the running game with RB Josh Jacobs averaging 66.5 Y/PG, and no other Green Bay rusher above the 20 YPG mark in 2025.
Per ESPN Analytics, Green Bay is a heavy favorite with an 80% chance of victory at Lambeau Field during the mid-afternoon window of football action.
Avoid: Detroit and Kansas City Matchup
The Kansas City Chiefs enter their Sunday Night Football matchup against the Detroit Lions as a 2.5 favorite as the host of the contest at GEHA Field at Arrowhead Stadium. The NFL schedule doesn’t get easier for the 2-3 Chiefs as the top team in the NFC North, the 4-1 Detroit Lions, saunter into Missouri. While it would need a turn around from Kansas City at this point, this contest was considered a Super Bowl LX preview entering the 2025 NFL season.
Despite the losing record, Kansas City is still favored by ESPN’s analytics model with a 55% chance to win. It should be a fascinating gridiron clash to watch, but it is best to avoid this Week 6 fight before playoff hopefuls.
Sports betting content is for entertainment purposes only. Gambling carries financial risk. Only wager what you can afford to lose and ensure you meet legal age restrictions and location requirements. If you or someone you know is struggling, please reach out to 1-877-846-7369 or TEXT 467369 (HOPENY).
For more on the the NFL, visit AMNY.com
