Fashionistas and artistas will descend on the Lower East Side on Sun., Sept. 8, for the second annual Lower East Side Opening Night: Art + Fashion. The cultural extravaganza will feature more than 40 fall art openings, plus an Orchard St. block party with a “Looks of the LES” fashion show, complete with models strutting on a runway. The “Looks” show, at 6:30 p.m., will feature the stylings of Robert James, The Cast and Quinn — no, not the mayoral candidate, the hip Orchard St. boutique. The block party will kick off at 4 p.m. on Orchard St. between Broome and Grand Sts., and will feature beats by Anton Bass of Sea to Sun Recordings and Onda Skillet, and live music by bands Heaven and Countdown Love. From 6 p.m. to 8 p.m., galleries throughout the neighborhood will be hosting their own individual receptions. For more information, visit https://www.lowereastsideny.com.