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Florida nightclub shooting: Donald Trump, Hillary Clinton and more politicians react to the attack

Politicians are speaking out following the mass shooting at a Florida nightclub that killed 49 people and wounded another 53.

The attack is the deadliest mass shooting in U.S. history.

Presidential candidates Donald Trump and Hillary Clinton were among the politicians who took to Twitter after learning the news. Scroll through to see what Trump, Clinton and others had to say about the attack.

Barack Obama

Photo Credit: Getty Images / Jim Watson

"The President was briefed this morning by Lisa Monaco, Assistant to the President for Homeland Security and Counterterrorism, on the tragic shooting in Orlando, Florida. Our thoughts and prayers are with the families and loved ones of the victims. The President asked to receive regular updates as the FBI, and other federal officials, work with the Orlando Police to gather more information, and directed that the federal government provide any assistance necessary to pursue the investigation and support the community," the press secretary said in a statement.

Joe Biden

Photo Credit: Getty Images / Jason Davis

"The Vice President was briefed this morning by his national security advisor on the heinous attack that took place overnight at a nightclub in Orlando, Florida. Vice President Biden offered his prayers for all those killed and injured in the shooting and sends his condolences to all the families and loved ones of the victims. He is closely monitoring the situation and will continue to receive regular updates as we know more," Biden's representative said in a statement.

Donald Trump

Photo Credit: Getty Images / Brian Blanco

"Really bad shooting in Orlando. Police investigating possible terrorism. Many people dead and wounded," Donald Trump tweeted. He later added, "Horrific incident in FL. Praying for all the victims & their families. When will this stop? When will we get tough, smart & vigilant?"

Hillary Clinton

Photo Credit: Getty Images / Justin Sullivan

"Woke up to hear the devastating news from FL. As we wait for more information, my thoughts are with those affected by this horrific act," Hillary Clinton tweeted.

Bernie Sanders

Photo Credit: Getty Images / Nicholas Kamm

"It's horrific, it's unthinkable," Bernie Sanders said on "Meet the Press."

Marco Rubio

Photo Credit: Getty Images / Robyn Beck

"Our prayers are with those injured and killed early this morning in horrifying act of terror in Orlando," Florida Sen. Marco Rubio tweeted. He also asked people in central Florida to donate blood.

Rick Scott

Photo Credit: Getty Images / Joe Raedle

"Our thoughts and prayers are with the victims, families and all those affected by this horrific tragedy," Florida Gov. Rick Scott said in a statement. "We are a strong and resilient state and we will devote every resource available to assist with the shooting in Orlando. Our state emergency operations center is also monitoring this tragic incident. I have been in constant communication with Orlando Mayor Buddy Dyer, Orange County Mayor Teresa Jacobs and state and local law enforcement this morning. I would like to also thank all the first responders who quickly came to assist and help those in need."

Mitt Romney

Photo Credit: Getty Images / Robert Giroux

"Deeply saddened to learn of the horrific attack in Orlando. Our hearts go out to those who lost loved ones," Mitt Romney tweeted.

Paul Ryan

Photo Credit: Getty Images / Nicholas Kamm

"We pray for those brutally attacked in Orlando. While we must learn more about the attacker, the victims & families will not be forgotten," House Speaker Paul Ryan tweeted.

Bill de Blasio

Photo Credit: Newsday / Alejandra Villa

"We mourn with the people of Orlando and the LGBT community as a whole on the news that -once again- we have lost precious lives to the gun," the mayor's office said on Twitter.

Andrew Cuomo

Photo Credit: Getty Images / Slaven Vlasic

"Saddened to hear of the senseless mass shooting in Orlando. My thoughts are with the victims, the injured and their loved ones," Gov. Andrew Cuomo said on Twitter.

Chuck Schumer

Photo Credit: Getty Images

"Horrified and saddened by the appalling attack at Orlando LGBT nightclub. Praying for the victims and their families," Sen. Chuck Schumer tweeted.

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