The New York Giants take to the road seeking their first road win of the 2025 NFL season, but it will be an extremely difficult test against the Detroit Lions at Ford Field in Michigan on Sunday afternoon. New York enters the contest after dropping a one-score contest to the Green Bay Packers in Week 11, while the Lions limited the Philadelphia Eagles to just one touchdown in a 16-9 loss on Sunday Night Football. Despite a 6-4 record, Detroit is still well positioned to fight for postseason positioning over the final six weeks of the NFL campaign.
Week 12: New York Giants (2-9) @ Detroit Lions (6-4)
Kick Off: 1:00 p.m. ET (Sun., 11/23/25)
Location: Ford Field (Detroit, Michigan)
The Lions take the field as nearly a two touchdown favorite (-12.5 points) over the visitors from New York. The over-under line is a bit inflated for this matchup at 49.5 points with Detroit possessing a top five-ranked offense, while New York sits near the middle of the pack offensively this season despite the injuries that have removed Malik Nabers and Cam Skattebo from the Giants offensive unit.
Green Bay has a plus .500 record against all three betting metrics this season. The Packers hold a 6-4 record against the spread and the moneyline, while being 5-5 against the over-under line. New York has performed admirably against the spread (5-6 record), and owns a winning mark against the over-under this season with a 6-5 mark. The Giants have been downright awful against the moneyline with a 2-9 record in the 2025 NFL season.
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NFL Week 12 Odds: Giants at Lions |
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| Spread | DET -12.5 |
| Moneyline | NYG +640, DET -950 |
| Over-Under Total | 49.5 points |
| Money Against the Spread | 90% DET |
| Bets Against the Spread | 77% DET |
| Odds via FanDuel Sportsbook | Odds are subject to change |
The Lions are home favorites with a 73% projection to win on Sunday, according to ESPN Analytics.
Best Bet: Jameis Winston 1 TD pass
Jameis Winston was inserted into the starting QB spot for New York in Week 11. The NFL veteran completed 19-of-29 pass attempts for 201 yards in a 27-20 loss to Green Bay. Winston added 10 yards on three carries, but one of those runs ended up in the painted area to add points to the scoreboard for New York.
Detroit features the eighth-best passing defense in the NFL entering Week 12. While it won’t be easy for Winston to find space, the Giants signal caller should have an opportunity to put some points on the board (particularly if New York gets down by multiple scores).
| NFL Week 12 Odds: Winston Passing TDs at Lions | |
| Winston 1+ Passing Touchdown | -340 |
| Winston 2+ Passing Touchdown | +162 |
| Winston 3+ Passing Touchdown | +630 |
| Odds via FanDuel Sportsbook | Odds subject to change |
This weekend’s matchup presents a difficult matchup for New York on the road against one of the better teams the NFC has to offer. However, with the competitive nature of the NFC North, Detroit could feel the pressure as they are currently looking upwards at the Chicago Bears at the top of the division table. If the Giants can keep the game close, they could steal a road win in Week 12.
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