News Brexit vote: Donald Trump, Hillary Clinton, more politicians react to Britain’s exit from EU By amNY.com staff with Reuters Updated June 24, 2016 11:49 AM Print Share fbShare Tweet Email Britain sent shock waves -- both politically and economically -- around the world on Friday when it voted to leave the European Union. The referendum's outcome quickly resulted in British Prime Minister David Cameron's resignation as well as reactions from politicians in the United States and around the world. Here is what they all had to say. David Cameron Photo Credit: Getty Images / Odd Anderson British Prime Minister David Cameron stood outside of 10 Downing St. and announced he would resign after the country's decision to leave the European Union. "The British people have made the very clear decision to take a different path and as such I think the country requires fresh leadership to take it in this direction," Cameron said during the televised address. President Barack Obama Photo Credit: Getty Images / Pool "The people of the United Kingdom have spoken, and we respect their decision," President Barack Obama said in a statement. Obama reassured the world that the United States and Britain will remain "indispensable partners." Donald Trump Photo Credit: Getty Images / Mark Wilson Presumptive Republican presidential nominee Donald Trump applauded Britain's decision to leave the European Union. "Self-determination is the sacred right of all free people, and the people of the UK have exercised that right for all the world to see." Trump said on Twitter. The real estate mogul followed up by tweeting: "America is proud to stand shoulder-to-shoulder w/a free & ind UK. We stand together as friends, as allies, & as a people w/a shared history." Hillary Clinton Photo Credit: Getty Images / Justin Sullivan Hillary Clinton focused on economic stability in her reaction to the Brexit vote. "Our first task has to be to make sure that the economic uncertainty created by these events does not hurt working families," the presumptive Democratic presidential nominee said on Twitter. Clinton had previously tweeted "We respect the choice the people of the United Kingdom have made" along with a photo of her full statement on the referendum. Vice President Joe Biden Photo Credit: Getty Images / Mark Wilson While traveling in Ireland, Vice President Joe Biden conceded the United States would have preferred that Britain had decided to stay in the European Union. "I must say we had looked for a different outcome. We would have preferred a different outcome ... but the United States has a long-standing friendship with the United Kingdom and that very special bond will endure," he said in a speech in Dublin. House Speaker Paul Ryan Photo Credit: Getty Images / Nicholas Kamm Trump wasn't the only Republican to speak on the Brexit vote Friday morning. House Speaker Paul Ryan vowed that the United States and Britain would remain close, saying "The UK is an indispensable ally of the United States, and that special relationship is unaffected by this vote." German Chancellor Angela Merkel Photo Credit: Getty Images / Carsten Koall German Chancellor Angela Merkel called the vote's outcome a watershed for European unification and invited French and Italian officials to Berlin as the European Union looks to move forward. French President Francois Hollande Photo Credit: Getty Images / Thierry Chesnot President Francois Hollande said the European Union must reinvent itself in the wake of Britain's decision to leave. "Europe must act quickly where it's needed and must, once and for all, let member states handle what is their exclusive domain," Hollande said in a televised address. By amNY.com staff with Reuters Share on Facebook Share on Twitter Comments We're revamping our Comments section. Learn more and share your input.